Scientists

Faculty Research Interest
Eran Andrechek
andrech1@msu.edu
eran andrechek
Asst Prof; Ph.D., McMasters University - Modeling mammary development and breast cancer using bioinformatic and genetic method.
David Arnosti
arnosti@msu.edu
David Arnosti
Prof; Ph.D., University of California, Berkeley - Eukaryotic gene regulation, transcriptional activation, and repression in Drosophila; function of retinoblastoma tumor suppressor genes in development.
C. Titus Brown
ctbrown@ucdavis.edu
c titus brown
Asst Prof; Ph.D., California Institute of Technology - We are working in the areas of microbial ecology (with metagenomics), evo-devo and disease (mRNAseq), and bacterial and animal genomics. We are increasingly interested in the question of how to educate biologists to work with data and tools.
Zachary F. Burton
burton@msu.edu
zachary burton
Prof; Ph.D., University of California, Los Angeles - Mechanism of elongation by human RNA polymerase II; regulation by transcription factor IIF and hepatitis delta antigen.
Christina Chan
krischan@egr.msu.edu
kristina chan
Prof; Ph.D., University of Pennsylvania - System biology approaches and tissue engineering platforms, reconstructing signaling and gene regulatory networks; understanding how fatty acids are involved in the development of Alzheimer's disease.
Ian Dworkin
idworkin@msu.edu
ian dworkin
Assoc Prof; Ph.D., University of Toronto - Our research focuses on using genetic and genomic approaches to address outstanding questions in the evolution of complex phenotypes. We primarily use Drosophila (among other systems) as a model system to examine the interplay of standing genetic variation and environmental heterogeneity and their contribution to trait expression and variation; and how this interaction is itself shaped by evolutionary forces such as natural selection and drift.
Monique Floer
floer@msu.edu
monique floer
Asst Prof; Ph.D., The Rockefeller University, New York - Analysis of the effects of chromatin architecture on gene expression in cells of the immune system.
James Geiger
geiger@chemistry.msu.edu
james geiger
Assoc Prof; Ph.D., Princeton University - The major focus of our research is to elucidate the structures of biologically important proteins, enzymes, enzyme/substrate, protein/ligand and protein/nucleic acid complexes. These high resolution structural "snap shots" reveal a wealth of information regarding the biology, mechanism and chemistry of these biological molecules and assemblies. We then take these insights and verify them by mutagenesis and various assays. We are also involved in applying our structural insights in protein design applications.
R. William Henry
henryw@msu.edu
r william henry
Assoc Prof; Ph.D., University of Alberta, Canada - Transcriptional regulation in eukaryotes; functions and architecture of basal transcription machinery; molecular determination of RNA polymerase specificity.
Gregg A. Howe
howeg@msu.edu
gregg howe
Prof; Ph.D. University of California, Los Angeles - Regulation of plant defense responses; biochemistry of jasmonic acid biosynthesis; plant-insect interactions.
Lauris S. Kaguni
lskaguni@msu.edu
laurie s kaguni
Prof; Ph.D., University of California, Los Angeles - Enzymology of mitochondrial DNA replication and transcription; organization and structure of mitochondrial DNA replication origins and promoters; DNA-protein interactions; regulation of DNA and RNA synthesis during Drosophila development.
Jason Knott
knottj@msu.edu
Jason Knott
Adj Asst Prof; Ph.D., University of Massachusetts - Epigenetic regulation of embryo development and stem cell pluripotency.

Lee Kroos
kroos@msu.edu
Lee Kroos

Prof; Ph.D., Stanford University - Signaling and gene regulatory mechanisms during bacterial development; intramembrane proteases of Bacillus subtilis; the network governing sporulation during Myxococcus xanthus fruiting body formation
Min-Hao Kuo
kuom@msu.edu
min-hao kuo
Assoc Prof; Ph.D., University of Rochester - Modifications and dynamics of chromatin; transcriptional regulation; proteomic interactions involving posttranslational modifications; tumor suppressor protein p53.
John J. LaPres
lapres@msu.edu
john j lapres
Assoc Prof; Ph.D., Northwestern University, Evanston, IL - Toxicology of transition metals and environmental pollutants; The role of hypoxia signaling in metal-induced toxicity, development, and cancer.
Erik Martinez-Hackert
emh@msu.edu
erik martinez hackert
Asst Prof; Ph.D., Rutgers University, New Jersey - Structural and biophysical properties of the Nodal interactome and its effects on signaling.
George I Mias
gmias@msu.edu

George I Mias
The Mias lab seeks to integrate existing and developing "-omics" technologies and their application in personalized medicine, aiding in the prediction, diagnosis and treatment of diseases as well as understanding disease onset and progression. We are developing novel methods for time-course analysis and applying these interdisciplinary approaches to integrate omics information. In addition to combining such data in a meaningful context for personalized medicine, we are also developing methods to study the biological interaction networks ascertained from the dynamical aspects of the data, by introducing new techniques from the study of critical phenomena and complex systems. The network transitions and information are directly related to the underlying diseases we are investigating, bridging the gap between the molecular level observation and physiological significance.
Amy Ralston
aralston@msu.edu
Amy Ralston

 
Origins and regulations of stem cells during mammalian development, reproduction and fertility, pluripotency.
Shin-Han Shiu
shius@msu.edu
shin-han shiu
Assoc Prof; Ph.D., University of Wisconsin-Madison - We are interested in answering how genomic changes contribute to physiological diversity and adaptation using photosynthetic organisms and yeast as model systems. Particularly, our focus is on the influence of environmental perturbations, such as changes in the abiotic or biotic conditions or nutrient availability in shaping genomes.
Brian C. Schutte
schutteb@msu.edu
brain schutte
Adj Assoc Prof; Ph.D., University of Wisconsin-Madison - MSU Dept. Microbiology & Molecular Genetics, - Genetics of common, complex human health conditions, especially cleft lip and palate and hearing loss, regulation of gene expression in mammals, function of Interferon Regulatory Factor 6.
Michael Thomashow
thomash6@msu.edu
michael thomashow
Prof; Ph.D., University of California, Los Angeles, CA - . Our overarching interest is to understand the molecular genetic mechanisms that plants have evolved to tolerate environmental stresses. Most of our effort focuses on the cold acclimation response, the process whereby certain plants increase in freezing tolerance upon exposure to low nonfreezing temperatures. However, as one of the cold response pathways that we are studying includes genes that impart drought tolerance, we are also interested in how plants sense and respond to water deficit.
Steven J. Triezenberg
steve.triezenberg@vai.org
steven triezenberg

 
Prof; Ph.D., The University of Michigan - Mechanisms of gene regulation in eukaryotes; transcriptional activation; herpes simplex virus; viral and cellular regulatory proteins; transcriptional adaptors and histone acetylation in plants.
Steve van Nocker
vannocke@msu.edu
steve van nocker
Prof; Ph.D., University of Wisconsin - What are the underlying genetic mechanisms that determine plant form, and how are these controlled? What are the key genes that influence agriculturally important traits such as flowering? What parallels exist between plant and human development, and can studies in plants shed light on issues such as cancer and stem cell biology?
Hua Xiao
xiaoh@msu.edu
hua xiao
Assoc Prof; Ph.D., University of Toronto; M.D. The Second Military Medical University (Shanghai, China). Molecular mechanisms and roles of transcriptional cofactors in breast and liver carcinogenesis; Mouse mammary gland development and tumor models.
Timothy R. Zacharewski
tzachare@msu.edu

tim zacharewski
Prof; Ph.D. Texas A&M University, College Station, Texas - Toxicogenomics; receptor-mediated toxicology; endocrine disruption; expression profiling; ligand-induced protein structure.